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Theoretical Biology and Medical Modelling

, 7:36

First Online: 20 August 2010Received: 17 March 2010Accepted: 20 August 2010DOI: 10.1186-1742-4682-7-36

Cite this article as: Patel, P., Biswas, R., Park, D. et al. Theor Biol Med Model 2010 7: 36. doi:10.1186-1742-4682-7-36

Abstract

BackgroundUltrasound elasticity imaging provides biomechanical and elastic properties of vascular tissue, with the potential to distinguish between tissue motion and tissue strain. To validate the ability of ultrasound elasticity imaging to predict structurally defined physical changes in tissue, strain measurement patterns during angioplasty in four bovine carotid artery pathology samples were compared to the measured physical characteristics of the tissue specimens.

MethodsUsing computational image-processing techniques, the circumferences of each bovine artery specimen were obtained from ultrasound and pathologic data.

ResultsUltrasound-strain-based and pathology-based arterial circumference measurements were correlated with an R value of 0.94 p = 0.03. The experimental elasticity imaging results confirmed the onset of deformation of an angioplasty procedure by indicating a consistent inflection point where vessel fibers were fully unfolded and vessel wall strain initiated.

ConclusionThese results validate the ability of ultrasound elasticity imaging to measure localized mechanical changes in vascular tissue.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4682-7-36 contains supplementary material, which is available to authorized users.

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Author: Prashant Patel - Rohan Biswas - Daewoo Park - Thomas J Cichonski - Michael S Richards - Jonathan M Rubin - Sem Phan - Ja

Source: https://link.springer.com/







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