Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamicsReport as inadecuate




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Theoretical Biology and Medical Modelling

, 7:21

First Online: 15 June 2010Received: 02 March 2010Accepted: 15 June 2010DOI: 10.1186-1742-4682-7-21

Cite this article as: Feizabadi, M.S. & Witten, T.M. Theor Biol Med Model 2010 7: 21. doi:10.1186-1742-4682-7-21

Abstract

BackgroundIn this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is considered from both the logistic and the Gompertzian case, while normal cell growth of fibroblasts WI-38 human diploid fibroblasts is considered as logistic only.

ResultsWe demonstrate, in a simple approach, how the interdependency of different cell types in a tumor, together with specifications of for treatment, can lead to different evolutionary patterns for normal and tumor cells during a course of therapy.

ConclusionsThese results have significance for understanding appropriate pharmacotherapy for elderly patients who are also undergoing chemotherapy.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4682-7-21 contains supplementary material, which is available to authorized users.

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Author: Mitra S Feizabadi - Tarynn M Witten

Source: https://link.springer.com/







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