Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3βReport as inadecuate




Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β - Download this document for free, or read online. Document in PDF available to download.

Mediators of InflammationVolume 2012 2012, Article ID 485279, 7 pages

Research Article

Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China

Intensive Care Unit, Wuxi Second Affiliated Hospital, Nanjing Medical University, Wuxi 210004, China

Department of clinical Laboratory, Wuxi Maternity and Child Health Affiliated Hospital, Nanjing Medical University, Wuxi 210004, China

Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China

Received 25 January 2012; Revised 20 March 2012; Accepted 28 March 2012

Academic Editor: Julio Galvez

Copyright © 2012 Liang Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress. In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and glycogen synthase kinase-3β and inhibited apoptosis in human umbilical vein endothelial cells induced by lipopolysaccharide. Calcium inhibition did not alter the antiapoptotic effect of activated protein C. The antiapoptotic efficiency of activated protein C was reduced in human umbilical vein endothelial cells following treatment with glycogen synthase kinase-3β-siRNA. In summary, activated protein C induced endoplasmic reticulum stress and attenuated lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis mediated by glycogen synthase kinase-3β.





Author: Liang Luo, Tangfeng Lv, Qian Wang, Ting Zhang, Xiaoling Gu, Feng Xu, and Yong Song

Source: https://www.hindawi.com/



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