Role of Chemokine Network in the Development and Progression of Ovarian Cancer: A Potential Novel Pharmacological TargetReport as inadecuate




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Journal of OncologyVolume 2010 2010, Article ID 426956, 15 pages

Review ArticleLaboratory of Pharmacology, Department of Oncology, Biology and Genetics, University of Genova, 16132 Genova, Italy

Received 11 June 2009; Accepted 28 September 2009

Academic Editor: Tian-Li Wang

Copyright © 2010 Federica Barbieri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ovarian cancer is the most common type of gynecologic malignancy. Despite advances in surgery and chemotherapy, the survival rate is still low since most ovarian cancers relapse and become drug-resistant. Chemokines are small chemoattractant peptides mainly involved in the immune responses. More recently, chemokines were also demonstrated to regulate extra-immunological functions. It was shown that the chemokine network plays crucial functions in the tumorigenesis in several tissues. In particular the imbalanced or aberrant expression of CXCL12 and its receptor CXCR4 strongly affects cancer cell proliferation, recruitment of immunosuppressive cells, neovascularization, and metastasization. In the last years, several molecules able to target CXCR4 or CXCL12 have been developed to interfere with tumor growth, including pharmacological inhibitors, antagonists, and specific antibodies. This chemokine ligand-receptor pair was also proposed to represent an innovative therapeutic target for the treatment of ovarian cancer. Thus, a thorough understanding of ovarian cancer biology, and how chemokines may control these different biological activities might lead to the development of more effective therapies. This paper will focus on the current biology of CXCL12-CXCR4 axis in the context of understanding their potential role in ovarian cancer development.





Author: Federica Barbieri, Adriana Bajetto, and Tullio Florio

Source: https://www.hindawi.com/



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