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BMC Research Notes

, 4:27

First Online: 31 January 2011Received: 21 August 2010Accepted: 31 January 2011DOI: 10.1186-1756-0500-4-27

Cite this article as: Lacasse, J.R. & Leo, J. BMC Res Notes 2011 4: 27. doi:10.1186-1756-0500-4-27

Abstract

BackgroundWhile the impact of conflicts-of-interest COI is of increasing concern in academic medicine, there is little research on the reaction of practicing clinicians to the disclosure of such conflicts. We developed two research vignettes presenting a fictional antidepressant medication study, one in which the principal investigator had no COI and another in which there were multiple COI disclosed. We confirmed the face validity of the COI vignette through consultation with experts. Hospital-based clinicians were randomly assigned to read one of these two vignettes and then administered a credibility scale.

FindingsPerceived credibility ratings were much lower in the COI group, with a difference of 11.00 points 31.42% on the credibility scale total as calculated through the Mann-Whitney U test 95% CI = 6.99 - 15.00, p < .001. Clinicians in the COI group were also less likely to recommend the antidepressant medication discussed in the vignette Odds Ratio = 0.163, 95% CI = .03 = 0.875.

ConclusionsIn this study, increased disclosure of COI resulted in lower credibility ratings.

AbbreviationsANOVAAnalysis of variance

COIconflict-of-interest

CIconfidence interval

GWghostwriting

KOLkey opinion leader

ORodds ratio

PCAprincipal components analysis

RRrelative risk

SNRIserotonin-norepinephrine reuptake inhibitor

SSRIselective serotonin reuptake inhibitor.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-4-27 contains supplementary material, which is available to authorized users.

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Author: Jeffrey R Lacasse - Jonathan Leo

Source: https://link.springer.com/



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