Smoking and drinking in relation to oral potentially malignant disorders in Puerto Rico: a case-control studyReport as inadecuate




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BMC Cancer

, 11:324

Epidemiology, prevention and public health

Abstract

BackgroundOral cancer incidence is high on the Island of Puerto Rico PR, particularly among males. As part of a larger study conducted in PR, we evaluated smoking and drinking as risk factors for oral potentially malignant disorders OPMDs.

MethodsPersons diagnosed with either an OPMD n = 86 oral epithelial dysplasia OED, oral hyperkeratosis-epithelial hyperplasia without OED or a benign oral tissue condition n = 155 were identified through PR pathology laboratories. Subjects were interviewed using a standardized, structured questionnaire that obtained information, including detailed histories of smoking and drinking. Odds ratios ORs for smoking and drinking in relation to having an OPMD, relative to persons with a benign oral tissue condition, were obtained using logistic regression and adjusted for age, gender, education, fruit-vegetable intake and smoking or drinking.

ResultsFor persons with an OPMD and relative to individuals with a benign oral tissue condition, the adjusted OR for current smoking was 4.32 95% CI: 1.99-9.38, while for former smokers, the ORadj was 1.47 95% CI: 0.67-3.21, each ORadj relative to never smokers. With regard to drinking, no adjusted ORs approached statistical significance, and few point estimates exceeded 1.0, whether consumption was defined in terms of ever, current, level drinks-week, or beverage type.

ConclusionsIn this study, conducted in Puerto Rico, current smoking was a substantial risk factor for OPMDs while former smokers had a considerably reduced risk compared to current smokers. There was little evidence suggesting that alcohol consumption was positively associated with OPMD risk.

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Author: Lin Li - Walter J Psoter - Carmen J Buxó - Augusto Elias - Lumarie Cuadrado - Douglas E Morse

Source: https://link.springer.com/







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