Serum selenium levels do not differ in type 2 diabetic subjects with and without coronary artery diseaseReport as inadecuate




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BMC Research Notes

, 4:270

First Online: 29 July 2011Received: 17 March 2011Accepted: 29 July 2011DOI: 10.1186-1756-0500-4-270

Cite this article as: Sotiropoulos, A., Papadodima, S.A., Papazafiropoulou, A.K. et al. BMC Res Notes 2011 4: 270. doi:10.1186-1756-0500-4-270

Abstract

BackgroundThe aim of the present study was to investigate whether selenium levels differ between type 2 diabetic subjects with and without coronary artery disease CAD.

MethodsA total of 200 subjects with type 2 diabetes 100 with CAD and 100 without CAD, consecutively selected from the diabetes outpatient clinic of our hospital were enrolled into the study. A detailed medical history and a physical examination were obtained by all the participants.

ResultsSerum selenium levels did not differ between diabetic subjects with and without CAD 102.40 ± 31.10 vs. 108.86 ± 33.88 microg-L, p = 0.16. In diabetic subjects with CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and sex beta = 0.21, p = 0.03 and glucose levels beta = 0.25, p = 0.008. In diabetic subjects without CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and peripheral artery disease beta = 0.16, p = 0.05 and glucose levels beta = -0.09, p = 0.05.

ConclusionSerum selenium levels did not differ between diabetic subjects with and without CAD. In diabetic subjects with CAD, the only determinants of serum selenium levels were sex and glucose levels. In diabetic subjects without CAD the only determinants of serum selenium levels were peripheral artery disease and glucose levels.

Keywordsselenium type 2 diabetes cardiovascular disease  Download fulltext PDF



Author: Alexios Sotiropoulos - Stavroula A Papadodima - Athanasia K Papazafiropoulou - Aggelos Ioannidis - Athanasia Kokkinari - Ou

Source: https://link.springer.com/







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