Lipohypertrophy in children and adolescents with type 1 diabetes and the associated factorsReport as inadecuate




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BMC Research Notes

, 4:290

First Online: 12 August 2011Received: 03 March 2011Accepted: 12 August 2011DOI: 10.1186-1756-0500-4-290

Cite this article as: Omar, M.A., El-Kafoury, A.A. & El-Araby, R.I. BMC Res Notes 2011 4: 290. doi:10.1186-1756-0500-4-290

Abstract

BackgroundDespite the important implications of lipohypertrophy for diabetes control, there is a dearth of information and research about the subject in children. The aim of this study was to study the prevalence of lipohypertrophy in children with type 1 diabetes, and to evaluate the associated factors.

Findings119 children coming for regular follow up in the diabetes clinic were examined for the presence of lipohypertrophy by inspection and palpation. The last 4 readings of glycated hemoglobin HbA1c levels and other factors that may affect lipohypertrophy were documented. RESULTS: The patient-s age ranged from 2 months to 21 years with a median of 10 years inter-quartile range = 6. Lipohypertrophy occurred in 54.9% of patients, more commonly in males 62.7% vs. females 48.4% P = 0.074. Grade 1 lipohypertrophy occurred in 42.5% and grade 2 in 12.4%. Lipohypertrophy was related significantly to the dose of insulin units per kg of body weight Odds ratio OR = 16.4; 95% CI, 2.2 - 124.6; P = 0.007, the duration of diabetes, OR = 1.16; 95% CI, 1.05 - 1.32; P = 0.004, and the body mass index BMI OR = 1.68; 95% CI, 1.25 - 2.15; P = 0.006. The mean HbA1c levels of patients with grade 1 and grade 2 lipohypertrophy did not differ from diabetics without lipohypertrophy F = 0.178, P = 0.837

ConclusionsThe presence of lipohypertrophy was significantly associated with the duration of diabetes and the body mass index. Children with lipohypertrophy needed a significantly higher dose of insulin units-kg of body weight to achieve fair control compared to children without lipohypertrophy. Further studies are needed to ascertain the clinical meaning of these findings.

List of abbreviationsHbA1cGlycated haemoglobin

BMIBody mass index.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-4-290 contains supplementary material, which is available to authorized users.

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Author: Magdy A Omar - Ahmed A El-Kafoury - Ramy I El-Araby

Source: https://link.springer.com/



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