Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cellsReport as inadecuate




Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cells - Download this document for free, or read online. Document in PDF available to download.

BMC Research Notes

, 5:168

First Online: 28 March 2012Received: 28 February 2012Accepted: 28 March 2012DOI: 10.1186-1756-0500-5-168

Cite this article as: Zou, J., Li, Y., Fan, HQ. et al. BMC Res Notes 2012 5: 168. doi:10.1186-1756-0500-5-168

Abstract

BackgroundDihydropyridine calcium channel blockers CCBs are more effective in reducing carotid intima-media thickness IMT than other classes of antihypertensive drugs due to their vascular effects. However, the mechanism remains to be elucidated.

FindingsOx-LDL induced HUVSMCs proliferation in a time- and dose-dependent manner. When pretreated with three CCBs before 50 μg-ml ox-LDL stimulation, 30 μM lacidipine and 3 μM amlodipine exhibited 27% and 18% decrease of pro-proliferative effect induced by ox-LDL, whereas S-amlodipine did not have any anti-proliferative effect. 30 μM lacidipine inhibited about two-thirds of the ox-LDL induced ROS production in HUVSMCs, whereas amlodipine and S-amlodipine did not have influence on ROS production. The MAPKs pathway inhibitors inhibited the ox-LDL induced proliferation of HUVSMCs.

ConclusionOur study has demonstrated that lipophilic CCBs, such as lacidipine may inhibit ox-LDL induced proliferation and oxidative stress of VSMCs, and that the ROS-MAPKs pathway might be involved in the mechanism.

KeywordsCalcium channel blockers Oxidative stress Oxidized low-density lipoprotein Proliferation Vascular smooth muscle cells Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-5-168 contains supplementary material, which is available to authorized users.

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Author: Jun Zou - Yan Li - Hong-Qi Fan - Ji-Guang Wang

Source: https://link.springer.com/



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