Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective studyReport as inadecuate




Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study - Download this document for free, or read online. Document in PDF available to download.

Journal of Translational Medicine

, 10:64

First Online: 30 March 2012Received: 10 October 2011Accepted: 30 March 2012DOI: 10.1186-1479-5876-10-64

Cite this article as: Jin, T., Lin, HX., Lin, H. et al. J Transl Med 2012 10: 64. doi:10.1186-1479-5876-10-64

Abstract

BackgroundThis study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 with clinical outcome in laryngeal squamous cell carcinoma SCC patients receiving postoperative radiotherapy.

MethodsImmunostaining with antibodies specific to BNIP3 and TGM2 was performed in formalin-fixed, paraffin-embedded specimens from 148 laryngeal SCC patients. BNIP3 and TGM2 expression was scored as high or low, based on the number of tumor cells stained and the staining intensity. All patients received postoperative radiotherapy. Patient follow up and clinicopathological data were compared using the Chi-squared test, univariate and multivariate analyses, and survival curves were generated using the Kaplan-Meier method and log-rank test.

ResultsThe 3, 5 and 10-year overall survival rates OS for all patients were 77.7%, 71.6%, 56.4%, respectively. Primary tumor site, T stage, overall stage, lymph-node metastasis, BNIP3 expression and TGM2 expression were significant prognostic factors for OS in univariate analysis. Negative cervical lymph nodes, high BNIP3 expression and low TGM2 expression were independent prognostic factors of improved OS in multivariate analysis. BNIP3 expression correlates with TGM2 expression in laryngeal SCC P = 0.012.

ConclusionsThis study indicates that lymph-node metastasis, BNIP3 expression and TGM2 expression are independent prognostic factors in laryngeal SCC patients receiving postoperative radiotherapy. Further studies are required to investigate how BNIP3 and-or TGM2 influence the prognosis of laryngeal SCC patients treated with postoperative radiotherapy, and to determine how TGM2 and BNIP3 expression are regulated.

KeywordsTGM2 BNIP3 Postoperative radiotherapy Laryngeal cancer Prognosis AbbreviationsPRTPostoperative radiotherapy

SCCSquamous cell carcinoma

HIF-1Hypoxia-inducible factor-1

TGM2Transglutaminase 2

NF-kBNuclear factor-kB

IHCImmunohistochemistry

UICCInternational Union Against Cancer

OSOverall survival.

Electronic supplementary materialThe online version of this article doi:10.1186-1479-5876-10-64 contains supplementary material, which is available to authorized users.

Ting Jin, Huan-Xin Lin, Hui Lin, Li-Bing Guo contributed equally to this work.

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Author: Ting Jin - Huan-Xin Lin - Hui Lin - Li-Bing Guo - Nan Ge - Xiu-Yu Cai - Rui Sun - Wen-Kuan Chen - Qiu-Li Li - Wei-Han Hu

Source: https://link.springer.com/







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