Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysisReport as inadecuate




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BMC Cancer

, 12:371

First Online: 27 August 2012Received: 02 March 2012Accepted: 21 August 2012DOI: 10.1186-1471-2407-12-371

Cite this article as: Chao, H.H., Uchio, E., Zhang, S. et al. BMC Cancer 2012 12: 371. doi:10.1186-1471-2407-12-371

Abstract

BackgroundDespite a lack of consensus regarding effectiveness, androgen deprivation therapy ADT is a common treatment for non-metastatic, low-risk prostate cancer. To examine a particular clinical concern regarding the possible impact of ADT on cognition, the current study combined neuropsychological testing with functional magnetic resonance imaging fMRI to assess both brain activation during cognitive performance as well as the integrity of brain connectivity.

MethodsIn a prospective observational cohort analysis of men with non-metastatic prostate cancer at a Veterans Affairs medical center, patients receiving ADT were compared with patients not receiving ADT at baseline and at 6 months. Assessments included fMRI, the N-back task for working memory, the stop-signal task for cognitive control, and a quality of life questionnaire.

ResultsAmong 36 patients enrolled 18 in each group, 30 completed study evaluations 15 in each group; 5 withdrew participation and 1 died. Results for the N-back task, stop-signal task, and quality of life were similar at 6 months vs. baseline in each group. In contrast, statistically significant associations were found between ADT use vs. non use and decreased medial prefrontal cortical activation during cognitive control, as well as decreased connectivity between the medial prefrontal cortex and other regions involved with cognitive control.

ConclusionsAlthough ADT for 6 months did not affect selected tests of cognitive function, brain activations during cognitive control and functional brain connectivity were impaired on fMRI. The long-term clinical implications of these changes are not known and warrant future study.

KeywordsAndrogen deprivation Prostate cancer Brain function Cognitive function Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-12-371 contains supplementary material, which is available to authorized users.

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Author: Herta H Chao - Edward Uchio - Sheng Zhang - Sien Hu - Sarah R Bednarski - Xi Luo - Michal Rose - John Concato - Chiang-s

Source: https://link.springer.com/







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