Association between physical and mental health-related quality of life and adverse outcomes; a retrospective cohort study of 5,272 Scottish adultsReport as inadecuate




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BMC Public Health

, 14:1197

Chronic Disease epidemiology

Abstract

BackgroundHealth-related quality of life HRQoL is associated with adverse outcomes in disease-specific populations. This study examines whether it is also independent predictor of incident cancer, coronary heart disease CHD and mortality in the general population.

MethodsThe records of adult participants in the Scottish Health Survey 2003 were linked with hospital admissions, cancer registrations and death certificates. Cox proportional hazard models were used to explore the associations between quintiles of physical and mental component summary score PCS and MCS respectively of the SF-12 and adverse outcomes. Higher quintiles of both PCS and MCS indicate better health status.

ResultsAmong the 5,272 study participants, the mean PCS score was 49 standard deviation SD 10.3. Participants were followed-up for a mean of 7.6 years. On survival analysis the lowest quintile of PCS was a strong predictor of all-cause death hazard ratio HR 2.81, 95% CI 1.76, 4.49, incident cancer HR 1.63, 95% CI 1.10, 2.42, and CHD events HR 1.99, 95% CI 1.00, 3.96, compared to the highest quintile. This association was independent of adiposity and other confounders. The mean MCS score 52 SD 8.8. MCS quintile was not associated with incident cancer and CHD, and the association between MCS and all-cause death HR 1.33, 95% CI 1.01, 1.75 became non-significant after adjustment for adiposity.

ConclusionPhysical HRQoL is a significant predictor of a range of adverse outcomes, even after adjustment for adiposity and other confounders. This study highlights the importance of perceived health in the general population.

KeywordsHealth-related quality of life HRQoL Scottish health survey Mortality Adverse outcomes AbbreviationsHRQoLHealth-related quality of life

CHDCoronary heart disease

SHSScottish Health Survey

PCSPhysical component summary

MCSMental component summary

HRHazard ratio

CIConfidence interval

BMIBody mass index

NHSNational Health Service

SMRScottish Morbidity Record

SIMDScottish Index of Multiple deprivation.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-14-1197 contains supplementary material, which is available to authorized users.

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Author: Zia Ul-Haq - Daniel F Mackay - Jill P Pell

Source: https://link.springer.com/







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