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Journal of Medical Case Reports

, 8:438

First Online: 18 December 2014Received: 24 September 2014Accepted: 27 October 2014DOI: 10.1186-1752-1947-8-438

Cite this article as: Fotakopoulos, G., Vagkopoulos, K., Gatos, C. et al. J Med Case Reports 2014 8: 438. doi:10.1186-1752-1947-8-438

Abstract

IntroductionEpendymomas are rare glial tumors of the brain representing less than 5% of brain tumors. However, spinal cord ependymomas in adults account for over 60% of all ependymomas including those arising from the filum terminale and only 40% are intracranial. Reports of the appearance of another neoplasia at a different location in patients with spinal ependymoma are scarce.

MethodsWe searched PubMed for studies related to spinal cord ependymomas published over the last 30 years from January 1984 and retrieved 1197.

ResultsWe identified only two studies that met our criteria and we found an incidence of 9% of secondary neoplasias after treatment for spinal ependymoma. The neoplasms were diagnosed from 2 months to 20 years after patients underwent surgery for intraspinal ependymoma. These included pancreatic cancer, prostate cancer, Hodgkin lymphoma, intracranial meningioma, mucin-producing pulmonary adenocarcinoma, gastric cancer and astrocytoma.

ConclusionsThe genetic abnormalities affecting patients with spinal ependymomas may indicate a predisposition to the development of secondary cancers or a general failure of the repairing mechanism in their DNA. The unaffected survival rates in those individuals permit for a long period the accumulation of different mutations on the genome and thus the appearance of a second cancer. However, more studies are needed, particularly in young patients with high survival rates.

KeywordsAnother neoplasia Secondary cancer Spinal ependymoma  Download fulltext PDF



Author: George Fotakopoulos - Konstantinos Vagkopoulos - Charalabos Gatos - Polikceni Kotlia - Alexandros Brotis

Source: https://link.springer.com/



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