Risk factors and correlates for anemia in HIV treatment-naïve infected patients: a cross-sectional analytical studyReport as inadecuate




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BMC Research Notes

, 3:230

First Online: 20 August 2010Received: 28 January 2010Accepted: 20 August 2010DOI: 10.1186-1756-0500-3-230

Cite this article as: Mata-Marín, J.A., Gaytán-Martínez, J.E., Martínez-Martínez, R.E. et al. BMC Res Notes 2010 3: 230. doi:10.1186-1756-0500-3-230

Abstract

BackgroundHematologic manifestations of the human immunodeficiency virus HIV infection are a well-recognized complication of the disease and may be clinically important. Our objective was to determine the risk factors for anemia and its correlation with HIV treatment-naïve infected patients without co-infection or opportunistic diseases.

FindingsWe performed a cross-sectional comparative study in which HIV treatment-naïve infected patients with anemia were compared with a control group of HIV patients without anemia. The interrelationship between risk factors and anemia was determined. Odds ratio and 95% confidence intervals were calculated, to adjust for the effects of potential confounders and we used a logistic regression model. Pearson-s correlation coefficient was obtained to calculate the correlation between risk factors and hemoglobin.

We enrolled 54 men and 9 women. Anemia was found in 13 patients; prevalence .20 CI 95% 0.12-0.32. Severe anemia was found in only one patient 1.5%. Only CD4+ Cells Count <200 cells-mm was associated with increased risk of anemia in the multivariate analysis. There was a moderately strong, positive correlation between WBC and hemoglobin r = 0.49, P < 0.001 and between CD4+ cell count and hemoglobin r = 0.595, P < 0.001 and a moderately strong, negative correlation between HIV RNA viral load and hemoglobin r = - 0.433, P < 0.001.

ConclusionsAnemia is a common manifestation in the Mexican population without antiretroviral therapy. In HIV naïve patients a CD4+ Cell Count < 200 cells-mm was associated with an increased risk of anemia. There is a positive correlation between hemoglobin and CD4+ cell count.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-3-230 contains supplementary material, which is available to authorized users.

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Author: José A Mata-Marín - Jesús E Gaytán-Martínez - Rosa E Martínez-Martínez - Carla I Arroyo-Anduiza - José L Fuentes

Source: https://link.springer.com/



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