Aortic thrombus in a patient with myeloproliferative thrombocytosis, successfully treated by pharmaceutical therapy: a case reportReport as inadecuate




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Journal of Medical Case Reports

, 4:219

First Online: 21 July 2010Received: 23 October 2009Accepted: 21 July 2010DOI: 10.1186-1752-1947-4-219

Cite this article as: Yamamoto, H., Nishimaki, H., Imai, N. et al. J Med Case Reports 2010 4: 219. doi:10.1186-1752-1947-4-219

Abstract

IntroductionThrombosis in myeloproliferative thrombocytosis occurs usually in the microvessels and medium-sized arteries and veins and only rarely in the aorta. Aortic thrombosis is usually treated with thrombectomy. Reported here is a rare case that was treated pharmacologically.

Case presentationA 60-year-old Japanese woman presented with numbness of both lower extremities. Her platelet count was 1787 × 10-μl. Through bone marrow examination, we diagnosed her condition as myelodysplastic and-or myeloproliferative disorder-unclassifiable. Abdominal ultrasonography and computed tomographic scan revealed aortic thrombosis. Her platelet count was controlled with hydroxyurea and ranimustine. Aspirin and ticlopidine improved the numbness in both lower limbs on the second day. Aortic thrombosis was not observed in a computed tomographic scan on the seventh day.

ConclusionFor aortic thrombosis, surgical management is usually adopted, but pharmacological management is also an option because of its immediate curative effects.

AbbreviationsCMPDchronic myeloproliferative disorder

COXcyclooxygenase

MDSmyelodysplastic syndrome

MDS-MPDmyelodysplastic-myeloproliferative disorder

MDS-MPNmyelodysplastic-myeloproliferative neoplasm

RARSrefractory anaemia with ringed sideroblasts

Uunclassifiable

WHOWorld Health Organization.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-4-219 contains supplementary material, which is available to authorized users.

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Author: Hidesuke Yamamoto - Haruaki Nishimaki - Norikazu Imai - Masakazu Nitta - Osami Daimaru

Source: https://link.springer.com/







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