Inflammatory findings on species extrapolations: humans are definitely no 70-kg miceReport as inadecuate




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Archives of Toxicology

, Volume 87, Issue 4, pp 563–567

First Online: 19 March 2013Received: 26 February 2013Accepted: 06 March 2013DOI: 10.1007-s00204-013-1038-0

Cite this article as: Leist, M. & Hartung, T. Arch Toxicol 2013 87: 563. doi:10.1007-s00204-013-1038-0

Abstract

Modern toxicology has embraced in vitro methods, and major hopes are based on the Omics technologies and systems biology approaches they bring along Hartung and McBride in ALTEX 282:83–93, 2011; Hartung et al. in ALTEX 292:119–28, 2012. A culture of stringent validation has been developed for such approaches Leist et al. in ALTEX 274:309–317, 2010; ALTEX 294:373–88, 2012a; Toxicol Res 1:8–22, 2012b, while the quality and usefulness of animal experiments have been little scrutinized. A new study Seok et al. 2013 now shows the low predictivity of animal responses in the field of inflammation. These findings corroborate earlier findings from comparisons in the fields of neurodegeneration, stroke and sepsis. The low predictivity of animal experiments in research areas allowing direct comparisons of mouse versus human data puts strong doubt on the usefulness of animal data as key technology to predict human safety.

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Author: Marcel Leist - Thomas Hartung

Source: https://link.springer.com/







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