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Cellular and Molecular Life Sciences

, Volume 70, Issue 10, pp 1675–1684

First Online: 12 March 2013Received: 15 January 2013Revised: 28 January 2013Accepted: 28 January 2013DOI: 10.1007-s00018-013-1277-5

Cite this article as: Ruhrberg, C. & Bautch, V.L. Cell. Mol. Life Sci. 2013 70: 1675. doi:10.1007-s00018-013-1277-5

Abstract

The developing central nervous system CNS is vascularized via ingression of blood vessels from the outside as the neural tissue expands. This angiogenic process occurs without perturbing CNS architecture due to exquisite cross-talk between the neural compartment and invading blood vessels. Subsequently, this intimate relationship also promotes the formation of the neurovascular unit that underlies the blood–brain barrier and regulates blood flow to match brain activity. This review provides a historical perspective on research into CNS blood vessel growth and patterning, discusses current models used to study CNS angiogenesis, and provides an overview of the cellular and molecular mechanisms that promote blood vessel growth and maturation. Finally, we highlight the significance of these mechanisms for two different types of neurovascular CNS disease.

KeywordsNeurovascular Neural tube Retina Hindbrain VEGF Semaphorins Neuropilin GPCR124 TGFβ  Download fulltext PDF



Author: Christiana Ruhrberg - Victoria L. Bautch

Source: https://link.springer.com/







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