Estimated birth weight and adult cardiovascular risk factors in a developing southern Chinese population: a cross sectional studyReport as inadecuate




Estimated birth weight and adult cardiovascular risk factors in a developing southern Chinese population: a cross sectional study - Download this document for free, or read online. Document in PDF available to download.

BMC Public Health

, 10:270

First Online: 24 May 2010Received: 12 January 2010Accepted: 24 May 2010DOI: 10.1186-1471-2458-10-270

Cite this article as: Schooling, C., Jiang, C., Lam, T. et al. BMC Public Health 2010 10: 270. doi:10.1186-1471-2458-10-270

Abstract

BackgroundBirth weight is negatively associated with cardiovascular diseases and diabetes, but the associations are less well-established in developing populations where birth weight is often unavailable. We studied the association of birth weight and cardiovascular risk, using birth rank as an instrumental variable, in Southern China.

MethodsWe used published data on birth weight by birth rank from an appropriate population and baseline data from the Guangzhou Biobank Cohort Study phases 2 and 3 2005-8 to examine the adjusted associations, using instrumental variable analysis, of birth weight with clinically measured cardiovascular risk factors and the metabolic syndrome in older ≥ 50 years men n = 5,051 and women n = 13,907.

ResultsEstimated birth weight was associated with lower blood pressure systolic -0.25 mm Hg 95% confidence interval CI -0.53 to 0.03 and diastolic -0.33 mm Hg 95% CI -0.48 to -0.18 per standard deviation higher birth weight, but had little association with glucose, lipids, waist-hip ratio, body mass index or the metabolic syndrome, adjusted for age, sex, early environment and number of offspring.

ConclusionBirth weight may impact blood pressure; however associations of birth weight with other cardiovascular risk factors may not be related to foetal exposures, but speculatively could be an historical co-incidence, with corresponding implications for prevention.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-10-270 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: CM Schooling - CQ Jiang - TH Lam - BJ Cowling - SL Au Yeung - WS Zhang - KK Cheng - GM Leung

Source: https://link.springer.com/







Related documents