Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research groupReport as inadecuate




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BMC Cancer

, 13:276

Infection, immunity and cancer vaccines

Abstract

BackgroundIt is not known whether children with acute promyelocytic leukemia APL have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly diagnosed APL and to describe factors associated with these infections.

MethodsWe conducted a retrospective, population-based cohort study that included children ≤ 18 years of age with de novo APL treated at 15 Canadian centers. Thirty-three children with APL were included; 78.8% were treated with APL -specific protocols.

ResultsBacterial sterile site infection occurred in 12 36.4% and fungal sterile site infection occurred in 2 6.1% children. Of the 127 chemotherapy courses, 101 79.5% were classified as intensive and among these, the proportion in which a sterile site microbiologically documented infection occurred was 14-101 13.9%. There was one infection-related death.

ConclusionsOne third of children with APL experienced at least one sterile site bacterial infection throughout treatment and 14% of intensive chemotherapy courses were associated with a microbiologically documented sterile site infection. Infection rates in pediatric APL may be lower compared to non- APL acute myeloid leukemia although these children may still benefit from aggressive supportive care during intensive chemotherapy.

KeywordsInfection Acute promyelocytic leukemia Bacteremia Sepsis Acute myeloid leukemia  Download fulltext PDF



Author: Sonia Cellot - Donna Johnston - David Dix - Marie-Chantal Ethier - Biljana Gillmeister - David Mitchell - Rochelle Yanofsky

Source: https://link.springer.com/



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