Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case reportReport as inadecuate




Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report - Download this document for free, or read online. Document in PDF available to download.

Journal of Medical Case Reports

, 4:89

First Online: 17 March 2010Received: 21 October 2009Accepted: 17 March 2010DOI: 10.1186-1752-1947-4-89

Cite this article as: Papantoniou, V.J., Sotiropoulou, E.K., Valsamaki, P.N. et al. J Med Case Reports 2010 4: 89. doi:10.1186-1752-1947-4-89

Abstract

IntroductionRecent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways.

Case presentationWe present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid, before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced, both visually and by semi-quantitative analysis, based on a calculation of lesion-to-background ratios.

ConclusionIn proliferating breast lesions, scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-4-89 contains supplementary material, which is available to authorized users.

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Author: Vassilios J Papantoniou - Evangelia K Sotiropoulou - Pipitsa N Valsamaki - Angeliki G Tsaroucha - Maria G Sotiropoulou -

Source: https://link.springer.com/



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