The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese populationReport as inadecuate




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BMC Public Health

, 10:139

First Online: 17 March 2010Received: 04 September 2009Accepted: 17 March 2010DOI: 10.1186-1471-2458-10-139

Cite this article as: Qian, Y., Lin, Y., Zhang, T. et al. BMC Public Health 2010 10: 139. doi:10.1186-1471-2458-10-139

Abstract

BackgroundDifferent populations have diverse patterns of relationships between Impaired Fasting Glucose IFG and obesity and lipid markers, it is important to investigate the characteristics of associations between IFG and other related risk factors including body mass index BMI, waist circumstance WC, serum lipids and blood pressure BP in a Chinese population.

MethodsThis was a case-control study of 648 IFG subjects and 1,296 controls derived from a large-scale, community-based, cross-sectional survey of 10,867 participants. Each subject received a face-to-face interview, physical examination, and blood tests, including fasting blood glucose and lipids. Student-s t-test, Chi-square test, Spearman correlation and multiple logistic regressions were used for the statistical analyses.

ResultsFasting plasma glucose FPG was positively correlated with BMI, WC, systolic blood pressure SBP, diastolic blood pressure DBP, triglyceride TG, and total cholesterol TC, and was negatively correlated with high density lipoprotein-cholesterol HDL-C all p < 0.05. BMI was more strongly correlated with IFG than with WC. The correlation coefficient of FPG was remarkably higher with TG 0.244 than with TC 0.134 and HDL-C -0.192. TG was an important predictor of IFG, with odds ratios of 1.76 95%CI: 1.31-2.36 for subjects with borderline high TG level 1.70 mmol-l ≤ TG < 2.26 mmol-l and 3.13 95% CI: 2.50-3.91 for those with higher TG level TG ≥ 2.26 mmol-l, when comparing to subjects with TG < 1.70 mmol-l. There was a significant dose-response relationship between the number of abnormal variables and increased risk of IFG.

ConclusionsIn this Chinese population, both BMI and WC were important predictors of IFG. Abnormal TG as a lipid marker was more strongly associated with IFG than were TC and HDL-C. These factors should be taken into consideration simultaneously for prevention of IFG.

AbbreviationsIFGimpaired fasting glucose

BMIbody mass index

WCwaist circumstance

BPblood pressure

SBPsystolic blood pressure

DBPdiastolic blood pressure

FPGfasting plasma glucose

TGtriglyceride

TCtotal cholesterol

HDL-Chigh density lipoprotein-cholesterol

CVDcardiovascular disease

ORodds ratio

CIconfidence interval.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-10-139 contains supplementary material, which is available to authorized users.

Yudi Lin, Tiemei Zhang, Jianling Bai, Feng Chen, Yi Zhang, Senlin Luo and Hongbing Shen contributed equally to this work.

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Author: Yun Qian - Yudi Lin - Tiemei Zhang - Jianling Bai - Feng Chen - Yi Zhang - Senlin Luo - Hongbing Shen

Source: https://link.springer.com/







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