Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case–control study in JapanReport as inadecuate




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BMC Cancer

, 13:337

Epidemiology, prevention and public health

Abstract

BackgroundIt is clear that genetic variations in the fat mass and obesity-associated FTO gene affect body mass index and the risk of obesity. Given the mounting evidence showing a positive association between obesity and pancreatic cancer, this study aimed to investigate the relation between variants in the FTO gene, obesity and pancreatic cancer risk.

MethodsWe conducted a hospital-based case–control study in Japan to investigate whether genetic variations in the FTO gene were associated with pancreatic cancer risk. We genotyped rs9939609 in the FTO gene of 360 cases and 400 control subjects. An unconditional logistic model was used to estimate the odds ratio OR and 95% confidence interval CI for the association between rs9939609 and pancreatic cancer risk.

ResultsThe minor allele frequency of rs9939609 was 0.18 among control subjects. BMI was not associated with pancreatic cancer risk. Compared with individuals with the common homozygous TT genotype, those with the heterozygous TA genotype and the minor homozygous AA genotype had a 48% OR=1.48; 95%CI: 1.07–2.04, and 66% increased risk OR=1.66; 95%CI: 0.70–3.90, respectively, of pancreatic cancer after adjustment for sex, age, body mass index, cigarette smoking and history of diabetes. The per-allele OR was 1.41 95%CI: 1.07–1.85. There were no significant interactions between TA-AA genotypes and body mass index.

ConclusionsOur findings indicate that rs9939609 in the FTO gene is associated with pancreatic cancer risk in Japanese subjects, possibly through a mechanism that is independent of obesity. Further investigation and replication of our results is required in other independent samples.

KeywordsThe fat mass and obesity-associated gene Pancreatic cancer rs9939609 Case–control study  Download fulltext PDF



Author: Yingsong Lin - Junko Ueda - Kiyoko Yagyu - Hiroshi Ishii - Makoto Ueno - Naoto Egawa - Haruhisa Nakao - Mitsuru Mori - Kei

Source: https://link.springer.com/



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