Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils of patients residential areas in TaiwanReport as inadecuate




Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils of patients residential areas in Taiwan - Download this document for free, or read online. Document in PDF available to download.

BMC Public Health

, 10:67

First Online: 12 February 2010Received: 06 July 2009Accepted: 12 February 2010DOI: 10.1186-1471-2458-10-67

Cite this article as: Su, CC., Lin, YY., Chang, TK. et al. BMC Public Health 2010 10: 67. doi:10.1186-1471-2458-10-67

Abstract

BackgroundTo explore if exposures to specific heavy metals in the environment is a new risk factor of oral cancer, one of the fastest growing malignancies in Taiwan, in addition to the two established risk factors, cigarette smoking and betel quid chewing.

MethodsThis is an observational study utilized the age-standardized incidence rates of oral cancer in the 316 townships and precincts of Taiwan, local prevalence rates of cigarette smoking and betel quid chewing, demographic factors, socio-economic conditions, and concentrations in farm soils of the eight kinds of heavy metal. Spatial regression and GIS Geographic Information System were used. The registration contained 22,083 patients, who were diagnosed with oral cancer between 1982 and 2002. The concentrations of metal in the soils were retrieved from a nation-wide survey in the 1980s.

ResultsThe incidence rate of oral cancer is geographically related to the concentrations of arsenic and nickel in the patients- residential areas, with the prevalence of cigarette smoking and betel quid chewing as controlled variables.

ConclusionsBeside the two established risk factors, cigarette smoking and betel quid chewing, arsenic and nickel in farm soils may be new risk factors for oral cancer. These two kinds of metal may involve in the development of oral cancer. Further studies are required to understand the pathways via which metal in the farm soils exerts its effects on human health.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-10-67 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Che-Chun Su - Yo-Yu Lin - Tsun-Kuo Chang - Chi-Ting Chiang - Jian-An Chung - Yun-Ying Hsu - Ie-Bin Lian

Source: https://link.springer.com/







Related documents