Risk of urinary bladder cancer: a case-control analysis of industry and occupationReport as inadecuate




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BMC Cancer

, 9:443

First Online: 15 December 2009Received: 15 August 2009Accepted: 15 December 2009DOI: 10.1186-1471-2407-9-443

Cite this article as: Cassidy, A., Wang, W., Wu, X. et al. BMC Cancer 2009 9: 443. doi:10.1186-1471-2407-9-443

Abstract

BackgroundUncertainty remains about urinary bladder cancer UBC risk for many occupations. Here, we investigate the association between occupation, industry and UBC.

MethodsLifetime occupational history was collected by in-person interview for 604 newly diagnosed UBC patients and 604 cancer-free controls. Each job title was assigned a two-digit industry code and a three-digit occupation code. Odds ratios ORs for UBC associated with ever being employed in an industry or occupation were calculated by unconditional logistic regression adjusting for age, gender and smoking status. We also examined UBC risk by duration of employment >0 to <10, ≥10 years in industry or occupation.

ResultsSignificantly increased risk of UBC was observed among waiters and bartenders OR 2.87; 95% CI 1.05 to 7.72 and occupations related to medicine and health OR 2.17; 95% CI 1.21 to 3.92, agricultural production, livestock and animal specialties OR 1.90; 95% CI 1.03 to 3.49, electrical assembly, installation and repair OR 1.69; 95% CI 1.07 to 2.65, communications OR 1.74; 95% CI 1.00 to 3.01, and health services OR 1.58; 95% CI 1.02 to 2.44. For these occupations we also observed a significant excess risk of UBC for long-term work i.e. ≥10 years, with the exception of waiters and bartenders. Employment for 10 years or more was associated with increased risk of UBC in general farmers OR 9.58; 95% CI 2.18 to 42.05, agricultural production of crops OR 3.36; 95% CI 1.10 to 10.27, occupations related to bench working OR 4.76; 95% CI 1.74 to 13.01, agricultural, fishery, forestry and related OR 4.58; 95% CI 1.97 to 10.65, transportation equipment OR 2.68; 95% CI 1.03 to 6.97, and structural work OR 1.85; 95% CI 1.16 to 2.95.

ConclusionsThis study provides evidence of increased risk of UBC for occupations that were previously reported as at-risk. Workers in several occupation and industry groups have a significantly higher risk of UBC, particularly when duration of employment is 10 years or more.

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Author: Adrian Cassidy - Wei Wang - Xifeng Wu - Jie Lin

Source: https://link.springer.com/







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