High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progressionReport as inadecuate




High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 9:385

First Online: 30 October 2009Received: 29 June 2009Accepted: 30 October 2009DOI: 10.1186-1471-2407-9-385

Cite this article as: Egerod, F.L., Bartels, A., Fristrup, N. et al. BMC Cancer 2009 9: 385. doi:10.1186-1471-2407-9-385

Abstract

BackgroundEgr-1 early growth response-1 transcription factor has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer have not been investigated. In the present study we investigated the expression levels of Egr-1 protein in early stages of human bladder cancer and correlated it to later progression.

MethodsExpression of Egr-1 protein in human bladder cancer was examined by immunohistochemistry, on a tissue microarray constructed from tumors from 289 patients with non-muscle invasive urothelial bladder cancer.

ResultsThe frequency of tumor cells with nuclear Egr-1 immunolabelling correlated to bladder cancer stage, grade and to later progression to muscle-invasive bladder cancer T2-4. Stage T1 tumors exhibited significantly higher frequencies of tumor cells with nuclear Egr-1 immunolabelling than Ta tumors P = 0.001. Furthermore, Kaplan-Meier survival analysis showed that a high frequency of tumor cells with nuclear Egr-1 immunolabelling was significantly associated with a higher risk of progression to stage T2-4 log-rank test, P = 0.035. Tumor cells with nuclear Egr-1 immunolabelling were found to localize at the tumor front in some of the tumor biopsies.

ConclusionThe results from this study support a potential involvement of Egr-1 in the progression from non-muscle invasive bladder cancers to muscle invasive bladder cancer.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-9-385 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Frederikke Lihme Egerod - Annette Bartels - Niels Fristrup - Michael Borre - Torben F Ørntoft - Martin B Oleksiewicz - N

Source: https://link.springer.com/







Related documents