Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literatureReport as inadecuate




Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 15:535

First Online: 22 July 2015Received: 25 November 2014Accepted: 09 July 2015DOI: 10.1186-s12885-015-1536-y

Cite this article as: Jia, N., Cormack, F.C., Xie, B. et al. BMC Cancer 2015 15: 535. doi:10.1186-s12885-015-1536-y

Abstract

BackgroundRenal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis FSGS or its morphological variant, collapsing focal segmental glomerulosclerosis CFSGS.

Case presentationWe describe a breast cancer patient who developed heavy proteinuria protein-creatinine ratio 9.1 and nephrotic syndrome following treatment with oral ibandronate for 29 months. CFSGS was proven by biopsy. There was no improvement 1 month after ibandronate was discontinued. Prednisone and tacrolimus were started and she experienced a decreased in proteinuria.

ConclusionIn patient who develops ibandronate-associated CFSGS, proteinuria appears to be at least partially reversible with the treatment of prednisone and-or tacrolimus if the syndrome is recognized early and ibandronate is stopped.

KeywordsCollapsing glomerulopathy Focal segmental glomerulosclerosis Bisphosphonates Ibandronate AbbreviationsFSGSFocal segmental glomerulosclerosis

CFSGSCollapsing focal segmental glomerulosclerosis

GAINThe German Intergroup Node-Positive

SWOGThe Southwest Oncology Group

ACAdriamycin and Cyclophosphamide

ANAAntibodies to nuclear antigens

PMOPost-menopausal osteoporosis

ATNAcute tubular necrosis

eGFRestimated glomerular filtration rate

MDRDModification of diet in renal disease

Download fulltext PDF



Author: Ning Jia - Fionnuala C. Cormack - Bin Xie - Zita Shiue - Behzad Najafian - Julie R. Gralow

Source: https://link.springer.com/







Related documents