Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevanceReport as inadecuate




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Journal of Translational Medicine

, 7:76

First Online: 28 August 2009Received: 27 June 2009Accepted: 28 August 2009DOI: 10.1186-1479-5876-7-76

Cite this article as: Dal-Bo, M., Bertoni, F., Forconi, F. et al. J Transl Med 2009 7: 76. doi:10.1186-1479-5876-7-76

Abstract

B-cell chronic lymphocytic leukemia CLL, the most frequent leukemia in the Western world, is characterized by extremely variable clinical courses with survivals ranging from 1 to more than 15 years. The pathogenetic factors playing a key role in defining the biological features of CLL cells, hence eventually influencing the clinical aggressiveness of the disease, are here divided into -intrinsic factors-, mainly genomic alterations of CLL cells, and -extrinsic factors-, responsible for direct microenvironmental interactions of CLL cells; the latter group includes interactions of CLL cells occurring via the surface B cell receptor BCR and dependent to specific molecular features of the BCR itself and-or to the presence of the BCR-associated molecule ZAP-70, or via other non-BCR-dependent interactions, e.g. specific receptor-ligand interactions, such as CD38-CD31 or CD49d-VCAM-1. A putative final model, discussing the pathogenesis and the clinicobiological features of CLL in relationship of these factors, is also provided.

Electronic supplementary materialThe online version of this article doi:10.1186-1479-5876-7-76 contains supplementary material, which is available to authorized users.

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Author: Michele Dal-Bo - Francesco Bertoni - Francesco Forconi - Antonella Zucchetto - Riccardo Bomben - Roberto Marasca - Silvia D

Source: https://link.springer.com/







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