Feasibility of isometric spinal muscle training in patients with bone metastases under radiation therapy - first results of a randomized pilot trialReport as inadecuate




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BMC Cancer

, 14:67

Clinical oncology

Abstract

BackgroundSpinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life ADL, reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot trial was to investigate the feasibility of muscle-training exercises in patients with spinal bone metastases under radiotherapy. Secondary endpoints were local control, pain response and survival.

MethodsThis study was a prospective, randomized, monocentre, controlled explorative intervention trial to determine the multidimensional effects of exercises for strengthening the paravertebral muscles. On the days of radiation treatment, patients in the control group were physically treated in form of respiratory therapy. Sixty patients were randomized between September 2011 and March 2013 into one of the two groups: differentiated resistance training or physical measure with thirty patients in each group.

ResultsThe resistance training of the paravertebral muscles was feasible in 83.3% of patients n = 25. Five patients died during the first three months. The exercise group experienced no measurable side effects. -Chair stand test- in the intervention group was significant enhanced with additionally improved analgesic efficiency. Patients in intervention group improved in pain score VAS, 0–10 over the course p < .001, and was significant better between groups p = .003 after 3 months. The overall pain response showed no significant difference between groups p = .158 There was no significant difference in overall and bone survival survival from first diagnosed bone metastases to death.

ConclusionsOur trial demonstrated safety and feasibility of an isometric resistance training in patients with spinal bone metastases. The results offer a rationale for future large controlled investigations to confirm these findings.

Trial registrationClinical trial identifier NCT01409720.

KeywordsBone metastases Spine Physical exercise Stability Isometric training Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-67 contains supplementary material, which is available to authorized users.

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