Leser-Trélat sign presenting in a patient with ovarian cancer: a case reportReport as inadecuate

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Journal of Medical Case Reports

, 3:8583

First Online: 23 July 2009Received: 28 February 2008Accepted: 09 February 2009DOI: 10.4076-1752-1947-3-8583

Cite this article as: Bölke, E., Gerber, P.A., Peiper, M. et al. J Med Case Reports 2009 3: 8583. doi:10.4076-1752-1947-3-8583


IntroductionSeborrheic keratoses are very common findings in elderly patients. However, a sudden onset and dramatic increase in the number and size of these benign lesions deserves special attention, since this may represent the Leser Trélat sign, a rare paraneoplastic cutaneous syndrome.

Case presentationA 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years. A diagnostic work-up revealed an ovarian carcinoma. Hence, cutaneous findings in our patient were consistent with the diagnosis of the Leser-Trélat sign.

ConclusionThe Leser-Trélat sign may coincide with the diagnosis of occult cancer or follow or precede it by months or years. Practitioners should take cases of eruptive seborrheic keratoses seriously and perform thorough patient examinations.

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Author: Edwin Bölke - Peter Arne Gerber - Matthias Peiper - Wolfram Trudo Knoefel - Mathias Cohnen - Christiane Matuschek - Wilfr

Source: https://link.springer.com/


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