Total antioxidant level is correlated with intra-ocular pressure in patients with primary angle closure glaucomaReport as inadecuate




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BMC Research Notes

, 7:163

First Online: 19 March 2014Received: 30 July 2013Accepted: 11 March 2014DOI: 10.1186-1756-0500-7-163

Cite this article as: Abu-Amero, K.K., Azad, T.A., Mousa, A. et al. BMC Res Notes 2014 7: 163. doi:10.1186-1756-0500-7-163

Abstract

BackgroundTo evaluate total antioxidant status TAS in the plasma of primary angle closure glaucoma PACG patients and to compare it to that of the control group. Additionally, we aim to investigate the association of various PACG clinical indices with TAS level.

MethodsPlasma samples were obtained from 139 PACG patients and 149 glaucoma-free controls of matching age, sex, and ethnicity. TAS in all samples was determined by spectrophotometric and enzyme-linked immunosorbent assay methods. We studied the possible association of the TAS level with various clinical indices relevant to PACG.

ResultsThe mean ±SD total antioxidant TAS value was almost similar in patients 1 ±0.22 compared to controls 0.97 ±0.43; p = 0.345. Among cases, mean TAS concentration showed a statistically significant lower pattern among subjects with glaucoma onset at the age of ≤ 50 years p = 0.037 and female subjects p = 0.014 as well as having a family history of glaucoma p = 0.010. Interestingly, a statistically significant inverse correlation was detected between TAS concentration and intra ocular pressure IOP, R = -0.14, p = 0.037.

ConclusionsThe inverse correlation of TAS level with IOP, highlights TAS potential role as a predictive-marker for PACG-severity.

KeywordsPACG Oxidative stress Anti-oxidant Glaucoma Saudi Arabia Abbreviationsc-dCup-to-disk ratio

EDTAEthylenediaminetetraacetic acid

H2O2Hydrogen peroxide

IOPIntra ocular pressure

KAUHKing Abdulaziz University Hospital

OROdds ratio

PACGPrimary angle closure glaucoma

POAGPrimary open angle glaucoma

TASTotal antioxidant status

TRAPTotal reactive antioxidant potential.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-7-163 contains supplementary material, which is available to authorized users.

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Author: Khaled K Abu-Amero - Taif Anwar Azad - Ahmed Mousa - Essam A Osman - Tahira Sultan - Saleh A Al-Obeidan

Source: https://link.springer.com/







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