High expression of AGR2 in lung cancer is predictive of poor survivalReport as inadecuate




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BMC Cancer

, 15:655

First Online: 06 October 2015Received: 10 October 2014Accepted: 28 September 2015DOI: 10.1186-s12885-015-1658-2

Cite this article as: Alavi, M., Mah, V., Maresh, E.L. et al. BMC Cancer 2015 15: 655. doi:10.1186-s12885-015-1658-2

Abstract

BackgroundAnterior gradient 2 AGR2 is a protein disulfide isomerase-like protein widely expressed in many normal tissues as well as cancers. In our study, non-neoplastic bronchial epithelial cells as well as non-small cell lung cancer NSCLC cells express AGR2 protein.

MethodsAGR2 expression was analyzed on lung tissue microarrays. Tumor staining was correlated with clinical outcomes.

ResultsOn a lung cancer tissue microarray using immunohistochemistry, expression levels in cancer showed generally decreasing intensities in order from adenocarcinomas with mucinous components, other adenocarcinomas, squamous carcinomas, to large cell carcinomas. The study cohort was comprised of 400 cases. As a group, there was a slight trend of lower expression with increasing tumor grade. AGR2 expression level was a significant predictor of overall survival in younger patients only. Patients under 65 with lower levels showed a significantly better survival for both men and women. Patients over 65, in contrast, showed no such trend.

ConclusionsNearly all NSCLC tumors show AGR2 expression. Lung cancer expression of AGR2 has prognostic value for younger patients.

KeywordsLung cancer AGR2 Survival AbbreviationsAGR2Anterior gradient 2

AUCArea under the curve

EGFREpidermal growth factor receptor

EREndoplasmic reticulum

ERαEstrogen receptor alpha

FOXA1FOXA2, forkhead box

GTumor grade

GIGastrointestinal

HRHazard ratio

IFI6Interferon alpha-inducible protein

MAST1Microtubule associated serine-threonine kinase

MUC2Mucin 2

NF-κBNuclear factor of kappa light polypeptide gene enhancer in B-cells

NSCLCNon-small cell lung cancer

PDIProtein disulfide isomerase

POU2AF1POU class 2 associating factor

SEMStandard error of the mean

SOAT2Sterol O-acyltransferase

SOX9Sex determining region Y-box

TMATissue microarray

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Author: Mohammed Alavi - Vei Mah - Erin L. Maresh - Lora Bagryanova - Steve Horvath - David Chia - Lee Goodglick - Alvin Y. Liu

Source: https://link.springer.com/







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