Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian CancerReport as inadecuate




Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 9:170

First Online: 06 June 2009Received: 19 December 2008Accepted: 06 June 2009DOI: 10.1186-1471-2407-9-170

Cite this article as: White, K.L., Vierkant, R.A., Phelan, C.M. et al. BMC Cancer 2009 9: 170. doi:10.1186-1471-2407-9-170

Abstract

BackgroundThe nuclear factor-κB NF-κB family is a set of transcription factors with key roles in the induction of the inflammatory response and may be the link between inflammation and cancer development. This pathway has been shown to influence ovarian epithelial tissue repair. Inhibitors of κB IκB prevent NF-κB activation by sequestering NF-κB proteins in the cytoplasm until IκB proteins are phosphorylated and degraded.

MethodsWe used a case-control study to evaluate the association between single nucleotide polymorphisms SNPs in NFKBIA and NFKBIB the genes encoding IκBα and IκBβ, respectively and risk of epithelial ovarian cancer. We queried 19 tagSNPs and putative-functional SNPs among 930 epithelial ovarian cancer cases and 1,037 controls from two studies.

ResultsThe minor allele for one synonymous SNP in NFKBIA, rs1957106, was associated with decreased risk p = 0.03.

ConclusionConsidering the number of single-SNP tests performed and null gene-level results, we conclude that NFKBIA and NFKBIB are not likely to harbor ovarian cancer risk alleles. Due to its biological significance in ovarian cancer, additional genes encoding NF-κB subunits, activating and inhibiting molecules, and signaling molecules warrant interrogation.

AbbreviationsNF-κBnuclear factor-κB

IL-10interleukin-10

TNFαtumor necrosis factor alpha

IκBinhibitors of κB

IL-1interleukin-1

TLRtoll-like receptor

TCRT cell receptor

IKKIκB kinase

SNPssingle-nucleotide polymorphisms

WGAwhole-genome amplification

MAFminor allele frequency

LDlinkage disequilibrium

QCquality control

ORsodd ratios

CIsconfidence intervals

d.f.degree-of-freedom.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-9-170 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Kristin L White - Robert A Vierkant - Catherine M Phelan - Brooke L Fridley - Stephanie Anderson - Keith L Knutson - Jo

Source: https://link.springer.com/



DOWNLOAD PDF




Related documents