Indoleamine 2,3-dioxygenase IDO is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort studyReport as inadecuate




Indoleamine 2,3-dioxygenase IDO is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 14:335

Translational oncology

Abstract

BackgroundRegulation of tumor microenvironment is closely involved in the prognosis of Hodgkin lymphoma HL. Indoleamine 2,3-dioxygenase IDO is an enzyme acting as immune modulator through suppression of T-cell immunity. This study aims to investigate role of IDO in the microenvironment of HL.

MethodsA total of 121 cases of HL were enrolled to do immunohistochemistry for IDO, CD163, CD68, CD4, CD8, and FoxP3. Positivity was evaluated from area fractions or numbers of positive cells using automated image analyzer. Correlations between IDO expression and various cellular infiltrates and clinicopathologic parameters were examined and survival analyses were performed.

ResultsIDO was expressed in histiocytes, dendritic cells and some endothelial cells with variable degrees, but not in tumor cells. IDO positive cells were more frequently found in mixed cellularity type than other histologic types, and in cases with EBV+, high Ann Arbor stages, B symptoms, and high IPS all p < 0.05. High IDO expression was associated with inferior survival p < 0.001 and reflects an independent prognostic factor in nodular sclerosis HL.

ConclusionsThis is the first study suggesting that IDO is the principle immunomodulator and is involved to adverse clinical outcomes of HL.

KeywordsHodgkin disease Indoleamine-pyrrole 2,3-dioxygenase Macrophages Stromal cells Tumor microenvironment Epstein-barr virus infections Pathology Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-335 contains supplementary material, which is available to authorized users.

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Author: Ji-Young Choe - Ji Yun Yun - Yoon Kyoung Jeon - Se Hoon Kim - Gyeongsin Park - Joo Ryoung Huh - Sohee Oh - Ji Eun Kim

Source: https://link.springer.com/







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