TTAn Polymorphism in 3-Hydroxy-3-Methylglutaryl-Coenzyme A and Response to Atorvastatin in Coronary Artery Disease PatientsReport as inadecuate




TTAn Polymorphism in 3-Hydroxy-3-Methylglutaryl-Coenzyme A and Response to Atorvastatin in Coronary Artery Disease Patients - Download this document for free, or read online. Document in PDF available to download.

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors have been used clinically for lowering total and low-density lipoprotein cholesterol. Interindividual pharmacological differences observed with this treatment have been attributed to genetic differences. The aim of this study was to assess the association in the low-density lipoprotein cholesterol reduction by atorvastatin and TTAn polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene in patients with coronary artery disease. Changes in total cholesterol levels, triglycerides, high-sensitivity C-reactive protein and free F-2-isoprostanes were also evaluated. In an open study, patients received 40 mg atorvastatin daily for 8 weeks. Genotyping was done through polymerase chain reaction. The genotype distribution of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase TTAn polymorphism was: > 10-> 10 in 22 out of 64 patients 34%, > 10-10 in 14 out of 64 patients 22% and 10-10 in 28 out of 64 patients 44%. The reduction of low-density lipoprotein cholesterol levels by atorvastatin was not different between allelic variants TTAn repeat polymorphism. Reductions in high-sensitivity C-reactive protein were observed in atorvastatin-treated patients with alleles > 10-> 10 and 10-10. Free F-2-isoprostanes and total cholesterol were also significantly lower after treatment for all alleles, irrespective of type of polymorphism. In conclusion, the changes induced by atorvastatin treatment on low-density lipoprotein cholesterol, total cholesterol, triglycerides, high-sensitivity C-reactive protein and free F-2-isoprostane concentrations were not related to the presence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase polymorphism TTAn.



Author: Noriega Sepúlveda, Viviana Carolina; - Llancaqueo Valeri, Marcelo; - Sánchez, P.; - Chiong Lay, Mario; - Prieto Domínguez, Jua

Source: http://repositorio.uchile.cl/



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