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Reference: Romano, F, Hudson, A, Doye, JP et al., (2012). The effect of topology on the structure and free energy landscape of DNA kissing complexes. The Journal of chemical physics, 136 (21), 215102.Citable link to this page:

 

The effect of topology on the structure and free energy landscape of DNA kissing complexes.

Abstract: We use a recently developed coarse-grained model for DNA to study kissing complexes formed by hybridization of complementary hairpin loops. The binding of the loops is topologically constrained because their linking number must remain constant. By studying systems with linking numbers -1, 0, or 1 we show that the average number of interstrand base pairs is larger when the topology is more favourable for the right-handed wrapping of strands around each other. The thermodynamic stability of the kissing complex also decreases when the linking number changes from -1 to 0 to 1. The structures of the kissing complexes typically involve two intermolecular helices that coaxially stack with the hairpin stems at a parallel four-way junction.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Accepted Manuscript Funder: Engineering and Physical Sciences Research Council   Notes:Copyright 2012 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in J. Chem. Phys. 136, 215102 (2012) and may be found at http://link.aip.org/link/?jcp/136/215102.

Bibliographic Details

Publisher: American Institute of Physics

Publisher Website: http://www.aip.org/

Journal: The Journal of chemical physicssee more from them

Publication Website: http://jcp.aip.org/

Issue Date: 2012-06

pages:215102Identifiers

Urn: uuid:1ba5018f-0375-4a2d-a24a-7faaef3faa87

Source identifier: 320486

Eissn: 1089-7690

Doi: https://doi.org/10.1063/1.4722203

Issn: 0021-9606 Item Description

Type: Journal article;

Language: eng

Version: Accepted ManuscriptKeywords: DNA Molecular Structure Thermodynamics Tiny URL: pubs:320486

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Author: Romano, F - - - Hudson, A - institutionUniversity of Oxford - - - Doye, JP - institutionUniversity of Oxford Oxford, MPLS, Chemis

Source: https://ora.ox.ac.uk/objects/uuid:1ba5018f-0375-4a2d-a24a-7faaef3faa87



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