Bioorthogonal chemistry: implications for pretargeted nuclear PET-SPECT imaging and therapy.Report as inadecuate




Bioorthogonal chemistry: implications for pretargeted nuclear PET-SPECT imaging and therapy. - Download this document for free, or read online. Document in PDF available to download.

Reference: Knight, JC and Cornelissen, B, (2014). Bioorthogonal chemistry: implications for pretargeted nuclear (PET/SPECT) imaging and therapy. American journal of nuclear medicine and molecular imaging, 4 (2), 96-113.Citable link to this page:

 

Bioorthogonal chemistry: implications for pretargeted nuclear (PET/SPECT) imaging and therapy.

Abstract: Due to their rapid and highly selective nature, bioorthogonal chemistry reactions are attracting a significant amount of recent interest in the radiopharmaceutical community. Over the last few years, reactions of this type have found tremendous utility in the construction of new radiopharmaceuticals and as a method of bioconjugation. Furthermore, reports are beginning to emerge in which these reactions are also being applied in vivo to facilitate a novel pretargeting strategy for the imaging and therapy of cancer. The successful implementation of such an approach could lead to dramatic improvements in image quality, therapeutic index, and reduced radiation dose to non-target organs and tissues. This review will focus on the potential of various bioorthogonal chemistry reactions to be used successfully in such an approach.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's version Funder: CancerResearch UK  

Bibliographic Details

Publisher: e-Century Publishing

Publisher Website: http://www.e-century.org/

Journal: American journal of nuclear medicine and molecular imagingsee more from them

Publication Website: http://www.ajnmmi.us/

Issue Date: 2014

pages:96-113Identifiers

Urn: uuid:28cea8ed-3108-4032-8651-a483830dfbc1

Source identifier: 462854

Eissn: 2160-8407 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: PET Pretargeting SPECT bioorthogonal chemistry click chemistry molecular imaging Tiny URL: pubs:462854

Relationships





Author: Knight, JC - institutionUniversity of Oxford Oxford, MSD, Oncology - - - Cornelissen, B - institutionUniversity of Oxford Oxford,

Source: https://ora.ox.ac.uk/objects/uuid:28cea8ed-3108-4032-8651-a483830dfbc1



DOWNLOAD PDF




Related documents