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Reference: Brooker, SJ, Pullan, RL, Gitonga, CW et al., (2012). Plasmodium-helminth coinfection and its sources of heterogeneity across East Africa. Journal of Infectious Diseases, 205 (5), 841-852.Citable link to this page:

 

Plasmodium-helminth coinfection and its sources of heterogeneity across East Africa.

Abstract: BACKGROUND: Plasmodium-helminth coinfection can have a number of consequences for infected hosts, yet our knowledge of the epidemiology of coinfection across multiple settings is limited. This study investigates the distribution and heterogeneity of coinfection with Plasmodium falciparum and 3 major helminth species across East Africa. METHODS: Cross-sectional parasite surveys were conducted among 28 050 children in 299 schools across a range of environmental settings in Kenya, Uganda, and Ethiopia. Data on individual, household, and environmental risk factors were collected and a spatially explicit Bayesian modeling framework was used to investigate heterogeneities of species infection and coinfection and their risk factors as well as school- and individual-level associations between species. RESULTS: Broad-scale geographical patterns of Plasmodium-helminth coinfection are strongly influenced by the least common infection and by species-specific environmental factors. At the individual level, there is an enduring positive association between P. falciparum and hookworm but no association between P. falciparum and Schistosoma species. However, the relative importance of such within-individual associations is less than the role of spatial factors in influencing coinfection risks. CONCLUSIONS: Patterns of coinfection seem to be influenced more by the distribution of the least common species and its environmental risk factors, rather than any enduring within-individual associations.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:Copyright © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: Oxford University Press

Publisher Website: http://www.oxfordjournals.org/

Journal: Journal of Infectious Diseasessee more from them

Publication Website: http://jid.oxfordjournals.org/

Issue Date: 2012-03

pages:841-852Identifiers

Urn: uuid:36298af3-b6c9-4342-ba70-33208aae20c4

Source identifier: 245836

Eissn: 1537-6613

Doi: https://doi.org/10.1093/infdis/jir844

Issn: 0022-1899 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Humans Plasmodium falciparum Schistosomiasis haematobia Schistosomiasis mansoni Malaria, Falciparum Uganda Hookworm Infections Adolescent Child Logistic Models Bayes Theorem Coinfection Ethiopia Kenya Risk Factors Female Male Tiny URL: pubs:245836

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Author: Brooker, SJ - - - Pullan, RL - - - Gitonga, CW - - - Ashton, RA - - - Kolaczinski, JH - - - Kabatereine, NB - - - Snow, RW - inst

Source: https://ora.ox.ac.uk/objects/uuid:36298af3-b6c9-4342-ba70-33208aae20c4



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