The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'Report as inadecuate




The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes' - Download this document for free, or read online. Document in PDF available to download.

Reference: Lori A. S. Snyder and Nigel J. Saunders, (2006). The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'. BMC Genomics, 7, Article: 128.Citable link to this page:

 

The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'

Abstract: Background: Neisseria meningitidis causes the life-threatening diseases meningococcal meningitis and meningococcal septicemia. Neisseria gonorrhoeae is closely related to the meningococcus, but is the cause of the very different infection, gonorrhea. A number of genes have been implicated in the virulence of these related yet distinct pathogens, but the genes that define and differentiate the species and their behaviours have not been established. Further, a related species, Neisseria lactamica is not associated with either type of infection in normally healthy people, and lives as a harmless commensal. We have determined which of the genes so far identified in the genome sequences of the pathogens are also present in this non-pathogenic related species.Results: Thirteen unrelated strains of N. lactamica were investigated using comparative genome hybridization to the pan-Neisseria microarray-v2, which contains 2845 unique gene probes. The presence of 127 'virulence genes' was specifically addressed; of these 85 are present in N. lactamica. Of the remaining 42 'virulence genes' only 11 are present in all four of the sequenced pathogenicNeisseria.Conclusion: Assessment of the complete dataset revealed that the vast majority of genes present in the pathogens are also present in N. lactamica. Of the 1,473 probes to genes shared by all four pathogenic genome sequences, 1,373 hybridize to N. lactamica. These shared genes cannot include genes that are necessary and sufficient for the virulence of the pathogens, since N. lactamica does not share this behaviour. This provides an essential context for the interpretation of genecomplement studies of the pathogens.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionNotes:© 2006 Snyder and Saunders; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Citation: Snyder, L. A. S. & Saunders, N. J. (2006). 'The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes', BMC Genomics, 7: 128. [Available at http://www.biomedcentral.com/1471-2164/7/128].

Bibliographic Details

Publisher: BioMed Central

Publisher Website: http://www.biomedcentral.com/

Host: BMC Genomicssee more from them

Publication Website: http://www.biomedcentral.com/1471-2164/7/128

Issue Date: 2006-May

Copyright Date: 2006

pages:Article: 128Identifiers

Doi: https://doi.org/10.1186/1471-2164-7-128

Issn: 1471-2164

Urn: uuid:3d80f55d-3ae5-4e44-b2a2-6f98f8d2b8ac Item Description

Type: Article: post-print;

Language: en

Version: Publisher's versionKeywords: bacterial pathogens Neisseria meningitidis Neisseria gonorrhoeae Neisseria lactamica 'virulence genes'Subjects: Pathology Tiny URL: ora:1780

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Author: Dr Lori A. S. Snyder - institutionUniversity of Oxford facultyMedical Sciences Division - Pathology - - - Dr Nigel J. Saunders -

Source: https://ora.ox.ac.uk/objects/uuid:3d80f55d-3ae5-4e44-b2a2-6f98f8d2b8ac



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