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Reference: Woll, PS, Kjällquist, U, Chowdhury, O et al., (2014). Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. Cancer cell, 25 (6), 794-808.Citable link to this page:

 

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Abstract: Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:Copyright © 2014 Elsevier Inc. Under Elsevier user license.

Bibliographic Details

Publisher: Cell Press

Publisher Website: http://www.cell.com/

Journal: Cancer cellsee more from them

Publication Website: http://www.cancercell.org/

Issue Date: 2014-06

pages:794-808Identifiers

Urn: uuid:67b3347a-b51c-4a0f-b5b4-741b4f8d5713

Source identifier: 465943

Eissn: 1878-3686

Doi: https://doi.org/10.1016/j.ccr.2014.03.036

Issn: 1535-6108 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Animals Mice, Inbred NOD Humans Mice Chromosomes, Human, Pair 5 Chromosome Deletion Myelodysplastic Syndromes Gene Expression Profiling Flow Cytometry Mutation Neoplastic Stem Cells Antigens, CD Heterografts Prognosis Genetic Predisposition to Disease Tiny URL: pubs:465943

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Author: Woll, PS - - - Kjällquist, U - - - Chowdhury, O - - - Doolittle, H - - - Wedge, DC - - - Thongjuea, S - - - Erlandsson, R - - -

Source: https://ora.ox.ac.uk/objects/uuid:67b3347a-b51c-4a0f-b5b4-741b4f8d5713



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