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Reference: Mohseni, HR, Smith, PP, Parsons, CE et al., (2012). MEG can map short and long-term changes in brain activity following deep brain stimulation for chronic pain. PloS one, 7 (6), e37993.Citable link to this page:

 

MEG can map short and long-term changes in brain activity following deep brain stimulation for chronic pain.

Abstract: Deep brain stimulation (DBS) has been shown to be clinically effective for some forms of treatment-resistant chronic pain, but the precise mechanisms of action are not well understood. Here, we present an analysis of magnetoencephalography (MEG) data from a patient with whole-body chronic pain, in order to investigate changes in neural activity induced by DBS for pain relief over both short- and long-term. This patient is one of the few cases treated using DBS of the anterior cingulate cortex (ACC). We demonstrate that a novel method, null-beamforming, can be used to localise accurately brain activity despite the artefacts caused by the presence of DBS electrodes and stimulus pulses. The accuracy of our source localisation was verified by correlating the predicted DBS electrode positions with their actual positions. Using this beamforming method, we examined changes in whole-brain activity comparing pain relief achieved with deep brain stimulation (DBS ON) and compared with pain experienced with no stimulation (DBS OFF). We found significant changes in activity in pain-related regions including the pre-supplementary motor area, brainstem (periaqueductal gray) and dissociable parts of caudal and rostral ACC. In particular, when the patient reported experiencing pain, there was increased activity in different regions of ACC compared to when he experienced pain relief. We were also able to demonstrate long-term functional brain changes as a result of continuous DBS over one year, leading to specific changes in the activity in dissociable regions of caudal and rostral ACC. These results broaden our understanding of the underlying mechanisms of DBS in the human brain.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Wellcome Trust   Funder: Engineering and Physical Sciences Research Council UK   Funder: TrygFonden Charitable Foundation   Funder: Medical Research Council   Funder: Norman Collisson Foundation   Funder: Charles Wolfson Charitable Trust   Notes:Copyright 2012 Mohseni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Bibliographic Details

Publisher: Public Library of Science

Publisher Website: http://www.plos.org

Journal: PloS onesee more from them

Publication Website: http://www.plosone.org

Issue Date: 2012

pages:e37993Identifiers

Urn: uuid:6afe97ba-5d43-4231-9973-3b8d34cfae0a

Source identifier: 334777

Eissn: 1932-6203

Doi: https://doi.org/10.1371/journal.pone.0037993

Issn: 1932-6203 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Humans Brain Magnetoencephalography Brain Mapping Deep Brain Stimulation Electrodes Middle Aged Time Factors Chronic Pain Male Tiny URL: pubs:334777

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Author: Mohseni, HR - institutionUniversity of Oxford Oxford, MSD, Psychiatry - - - Smith, PP - institutionUniversity of Oxford Oxford, M

Source: https://ora.ox.ac.uk/objects/uuid:6afe97ba-5d43-4231-9973-3b8d34cfae0a



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