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Reference: Chen, WC, Foxley, S and Miller, KL, (2013). Detecting microstructural properties of white matter based on compartmentalization of magnetic susceptibility. NeuroImage, 70, 1-9.Citable link to this page:

 

Detecting microstructural properties of white matter based on compartmentalization of magnetic susceptibility.

Abstract: The microscopic structure of neuronal tissue is crucial to brain function, with axon diameter, axonal density and myelination directly influencing signal conduction in the white matter. There is increasing evidence that these microstructural properties alter signal in magnetic resonance imaging (MRI) driven by magnetic susceptibility of different compartments (e.g., myelin sheaths and iron-laden cells). To explain these observations, we have developed a multi-compartmental geometric model of whitematter microstructure. Using a single set of literature parameters, this forward model predicts experimentally observed orientation dependence and temporal evolution of the MRI signal. Where previous models have aimed to explain only the orientation dependence of signal phase, the proposed approach encapsulates the full repertoire of signal behavior. The frequency distribution underlying signal behavior is predicted to be a rich source of microstructural information with relevance to neuronal pathology.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher versionNotes:Copyright 2012 Elsevier Inc. Open access under CC BY license.

Bibliographic Details

Publisher: Elsevier B.V.

Publisher Website: https://www.elsevier.com/

Journal: NeuroImagesee more from them

Publication Website: http://www.sciencedirect.com/science/journal/10538119

Issue Date: 2013-4

Article Number:C

pages:1-9Identifiers

Urn: uuid:7d4346c4-c26b-4e6b-9354-3f2fe30594cf

Source identifier: 369934

Eissn: 1095-9572

Doi: https://doi.org/10.1016/j.neuroimage.2012.12.032

Issn: 1053-8119 Item Description

Type: Journal article;

Language: eng

Version: Publisher versionKeywords: Axons Nerve Fibers, Myelinated Humans Magnetic Resonance Imaging Models, Neurological Tiny URL: pubs:369934

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Author: Chen, WC - institutionUniversity of Oxford - - - Foxley, S - institutionUniversity of Oxford Oxford, MSD, Clinical Neurosciences

Source: https://ora.ox.ac.uk/objects/uuid:7d4346c4-c26b-4e6b-9354-3f2fe30594cf



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