The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expressionReport as inadecuate




The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression - Download this document for free, or read online. Document in PDF available to download.

Reference: Vecellio, M, Roberts, AR, Cohen, CJ et al., (2015). The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression. Annals of the Rheumatic Diseases.Citable link to this page:

 

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression

Abstract: Objectives: To identify the functional basis for the genetic association of single nucleotide polymorphisms (SNP), upstream of the RUNX3 promoter, with ankylosing spondylitis (AS).Methods: We performed conditional analysis of genetic association data and used ENCODE data on chromatin remodelling and transcription factor (TF) binding sites to identify the primary AS-associated regulatory SNP in the RUNX3 region. The functional effects of this SNP were tested in luciferase reporter assays. Its effects on TF binding were investigated by electrophoretic mobility gel shift assays and chromatin immunoprecipitation. RUNX3 mRNA levels were compared in primary CD8+ T cells of AS risk and protective genotypes by real-time PCR.Results: The association of the RUNX3 SNP rs4648889 with AS (p



Author: Vecellio, M - institutionUniversity of Oxford Oxford, MSD, NDORMS fundingNIHR Oxford Comprehensive Biomedical Research Centre - -

Source: https://ora.ox.ac.uk/objects/uuid:8a9ba3ab-6ee4-4df0-a1ee-1c73687dcb0a



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