Diet and risk of divericular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition EPIC: prospective study of British vegetarians and non-vegetariansReport as inadecuate




Diet and risk of divericular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition EPIC: prospective study of British vegetarians and non-vegetarians - Download this document for free, or read online. Document in PDF available to download.

Reference: Francesca L. Crowe, Paul N. Appleby, Naomi E. Allen et al., (2011). Diet and risk of divericular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians. BMJ, 343, Article: d4131.Citable link to this page:

 

Diet and risk of divericular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians

Abstract: Objective: To examine the associations of a vegetarian diet and dietary fibre intake with risk of diverticular disease.Design: Prospective cohort study.Setting: The EPIC-Oxford study, a cohort of mainly health conscious participants recuited from around the United Kingdom.Participants: 47033 men and women living in England or Scotland of whom 15459 (33%) reported consuming a vegetarian diet.Main outcome measures: Diet group was assessed at baseline; intake of dietary fibre was estimated from a 130 item validated food frequency questionnaire. Cases of diverticular disease were identified through linkage with hospital records and death certificates. Hazard ratios and 95% confidence intervals for the risk of diverticular disease by diet group and fifths of intake dietary fibre were estimated with multivariate Cox proportional hazards regression models.Results: After a mean follow-up time of 11.6 years, there were 812 cases of diverticular disease (806 admissions to hospital and six deaths). After adjustment for confounding variables, vegetarians had a 31% lower risk (relative risk 0.69, 95% confidence interval 0.55 to 0.86) of diverticular disease compared with meat eaters. The cumulative probability of admission to hospital or death from diverticular disease between the ages of 50 and 70 for meat eaters was 4.4% compared with 3% for vegetarians. There was also an inverse association with dietary fibre intake; participants in the highest fifth (≥25.5 g/day for women and ≥26.1 g/day for men) had a 41% lower risk (0.59, 0.46 to 0.78; P



Author: Francesca L. Crowe - institutionUniversity of Oxford facultyMedical Sciences Division - Clinical Medicine,Nuffield Department of

Source: https://ora.ox.ac.uk/objects/uuid:97eaa3ae-96fc-4df1-9f52-ac81bd390d89



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