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Reference: Boorman, ED, O'Shea, J, Sebastian, C et al., (2007). Individual differences in white-matter microstructure reflect variation in functional connectivity during choice. Current biology : CB, 17 (16), 1426-1431.Citable link to this page:

 

Individual differences in white-matter microstructure reflect variation in functional connectivity during choice.

Abstract: The relation between brain structure and function is of fundamental importance in neuroscience. Comparisons between behavioral and brain-imaging measures suggest that variation in brain structure correlates with the presence of specific skills. Behavioral measures, however, reflect the integrated function of multiple brain regions. Rather than behavior, a physiological index of function could be a more sensitive and informative measure with which to compare structural measures. Here, we test for a relationship between a physiological measure of functional connectivity between two brain areas during a simple decision-making task and a measure of structural connectivity. Paired-pulse transcranial magnetic stimulation indexed functional connectivity between two regions important for action choices: the premotor and motor cortex. Fractional anisotropy (FA), a marker of microstructural integrity, indexed structural connectivity. Individual differences in functional connectivity during action selection show highly specific correlations with FA in localized regions of white-matter interconnecting regions, including the premotor and motor cortex. Probabilistic tractography, a technique for identifying fiber pathways from diffusion-weighted imaging (DWI), was used to reconstruct the anatomical networks linking the component brain regions involved in making decisions. These findings demonstrate a relationship between individual differences in functional and structural connectivity within human brain networks central to action choice.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:Copyright 2007 Elsevier B.V. All rights reserved. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www.elsevier.com/open-access/userlicense/1.0/

Bibliographic Details

Publisher: Elsevier B.V.

Publisher Website: http://www.elsevier.com/

Journal: Current biology : CBsee more from them

Publication Website: http://www.sciencedirect.com/science/journal/09609822

Issue Date: 2007-8

pages:1426-1431Identifiers

Urn: uuid:9930df50-4afb-4484-b5b3-5b78d819cbec

Source identifier: 240832

Eissn: 1879-0445

Doi: https://doi.org/10.1016/j.cub.2007.07.040

Issn: 0960-9822 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Humans Motor Cortex Neural Pathways Magnetic Resonance Imaging Brain Mapping Choice Behavior Individuality Adult Transcranial Magnetic Stimulation Female Male Tiny URL: pubs:240832

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Author: Boorman, ED - institutionUniversity of Oxford Oxford, MSD, Clinical Neuroscience fundingWellcome Trust - - - O'Shea, J - inst

Source: https://ora.ox.ac.uk/objects/uuid:9930df50-4afb-4484-b5b3-5b78d819cbec



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