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Reference: Thanh, DP, Thompson, CN, Rabaa, MA et al., (2016). The molecular and spatial epidemiology of typhoid fever in rural Cambodia. PLoS Neglected Tropical Diseases.Citable link to this page:

 

The molecular and spatial epidemiology of typhoid fever in rural Cambodia

Abstract: Typhoid fever, caused by the bacterium Salmonella Typhi, is an endemic cause of febrile disease in Cambodia. The aim of this study was to better understand the epidemiology of pediatric typhoid fever in Cambodia. We accessed routine blood culture data from Angkor Hospital for Children (AHC) in Siem Reap province between 2007 and 2014, and performed whole genome sequencing (WGS) on the isolated bacteria to characterize the S. Typhi population. The resulting phylogenetic information was combined with conventional epidemiological approaches to investigate the spatiotemporal distribution of S. Typhi and population-level risk factors for reported disease. During the study period, there were 262 cases of typhoid within a 100 km radius of AHC, with a median patient age of 8.2 years (IQR: 5.1–11.5 years). The majority of infections occurred during the rainy season, and commune incidences as high as 11.36/1,000 in children aged



Author: Thanh, DP - institutionUniversity of Oxford Oxford, MSD, NDM, Tropical Medicine, Vietnam - OUCRU - - - Thompson, CN - institution

Source: https://ora.ox.ac.uk/objects/uuid:b7d928f1-eb01-42eb-9d8e-e75180040856



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