Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old childrenReport as inadecuate




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Reference: Donin, AS, Dent, JE, Nightingale, CM et al., (2015). Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children. Diabetic Medicine, 33 (3), 307–315.Citable link to this page:

 

Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin restance and glycaemia in 9-10 year-old children

Abstract: AimTo examine whether low circulating vitamin C concentrations and low fruit and vegetable intakes were associated with insulin resistance and other Type 2 diabetes risk markers in childhood.MethodsWe conducted a cross-sectional, school-based study in 2025 UK children aged 9–10 years, predominantly of white European, South-Asian and black African origin. A 24-h dietary recall was used to assess fruit, vegetable and vitamin C intakes. Height, weight and fat mass were measured and a fasting blood sample collected to measure plasma vitamin C concentrations and Type 2 diabetes risk markers.ResultsIn analyses adjusting for confounding variables (including socio-economic status), a one interquartile range higher plasma vitamin C concentration (30.9 µmol/l) was associated with a 9.6% (95% CI 6.5, 12.6%) lower homeostatic model assessment of insulin resistance value, 0.8% (95% CI 0.4, 1.2%) lower fasting glucose, 4.5% (95% CI 3.2, 5.9%) lower urate and 2.2% (95% CI 0.9, 3.4%) higher HDL cholesterol. HbA1c concentration was 0.6% (95% CI 0.2, 1.0%) higher. Dietary fruit, vegetable and total vitamin C intakes were not associated with any Type 2 diabetes risk markers. Lower plasma vitamin C concentrations in SouthAsian and black African-Caribbean children could partly explain their higher insulin resistance.ConclusionsLower plasma vitamin C concentrations are associated with insulin resistance and could partly explain ethnic differences in insulin resistance. Experimental studies are needed to establish whether increasing plasma vitamin C can help prevent Type 2 diabetes at an early stage.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Accepted manuscript Funder: Diabetes UK   Funder: Wellcome Trust   Funder: National Prevention Research Initiative   Funder: British Heart Foundation   Funder: Cancer Research UK   Funder: Department of Health   Funder: Economic and Social Research Council   Funder: Medical Research Council   Funder: Research and Development Office for the Northern Ireland Health and Social Services   Funder: Chief Scientist Office (Scottish Executive Health Department)   Funder: Welsh Assembly Government   Notes:© 2015 The Authors. Diabetic Medicine published by John Wiley and Sons Ltd on behalf of Diabetes UK. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: Wiley

Publisher Website: http://www.wiley.com/

Journal: Diabetic Medicinesee more from them

Publication Website: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1464-5491

Volume: 33

Issue: 3

Extent: 307–315

Issue Date: 2015-10

pages:307–315Identifiers

Urn: uuid:be63f051-1632-4edc-9614-a99e16427b1c

Source identifier: 612207

Eissn: 1464-5491

Doi: https://doi.org/10.1111/dme.13006 Item Description

Type: Journal article;

Version: Accepted manuscript Tiny URL: pubs:612207

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Author: Donin, AS - - - Dent, JE - - - Nightingale, CM - - - Sattar, N - - - Owen, CG - - - Rudnicka, AR - - - Perkin, MR - - - Stephen,

Source: https://ora.ox.ac.uk/objects/uuid:be63f051-1632-4edc-9614-a99e16427b1c



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