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Reference: Lorenzo-Redondo, R, Fryer, HR, Bedford, T et al., (2016). Persistent HIV-1 replication maintains the tissue reservoir during therapy. Nature, 530 (7588), 51-56.Citable link to this page:

 

Persistent HIV-1 replication maintains the tissue reservoir during therapy.

Abstract: Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in immune complexes, and viral persistence. Although combinations of antiretroviral drugs usually suppress viral replication and reduce viral RNA to undetectable levels in blood, it is unclear whether treatment fully suppresses viral replication in lymphoid tissue reservoirs. Here we show that virus evolution and trafficking between tissue compartments continues in patients with undetectable levels of virus in their bloodstream. We present a spatial and dynamic model of persistent viral replication and spread that indicates why the development of drug resistance is not a foregone conclusion under conditions in which drug concentrations are insufficient to completely block virus replication. These data provide new insights into the evolutionary and infection dynamics of the virus population within the host, revealing that HIV-1 can continue to replicate and replenish the viral reservoir despite potent antiretroviral therapy.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Accepted manuscriptNotes:© the Author(s). This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: [10.1038/nature16933]

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website: http://www.nature.com/

Journal: Naturesee more from them

Publication Website: http://www.nature.com/nature/index.html

Volume: 530

Issue: 7588

Extent: 51-56

Issue Date: 2016-01-27

pages:51-56Identifiers

Urn: uuid:ccf8e5dc-ba09-45e2-adfd-1f25bd2d1221

Source identifier: 601366

Eissn: 1476-4687

Doi: https://doi.org/10.1038/nature16933

Issn: 0028-0836 Item Description

Type: Journal article;

Language: eng

Version: Accepted manuscriptKeywords: Lymph Nodes Humans HIV-1 HIV Infections Anti-HIV Agents Viral Load Sequence Analysis, DNA Carrier State Phylogeny Drug Resistance, Viral Virus Replication Haplotypes Models, Biological Time Factors Molecular Sequence Data Selection, Genetic Spatio-Temporal Analysis SBTMR Tiny URL: pubs:601366

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Author: Lorenzo-Redondo, R - - - Fryer, HR - institutionUniversity of Oxford Oxford, MPLS, Zoology - - - Bedford, T - - - Kim, EY - - - A

Source: https://ora.ox.ac.uk/objects/uuid:ccf8e5dc-ba09-45e2-adfd-1f25bd2d1221



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