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Reference: Kaess, BM, Tomaszewski, M, Braund, PS et al., (2011). Large-scale candidate gene analysis of HDL particle features. PloS one, 6 (1), Article: e14529.Citable link to this page:

 

Large-scale candidate gene analysis of HDL particle features.

Abstract: BACKGROUND: HDL cholesterol (HDL-C) is an established marker of cardiovascular risk with significant genetic determination. However, HDL particles are not homogenous, and refined HDL phenotyping may improve insight into regulation of HDL metabolism. We therefore assessed HDL particles by NMR spectroscopy and conducted a large-scale candidate gene association analysis. METHODOLOGY/PRINCIPAL FINDINGS: We measured plasma HDL-C and determined mean HDL particle size and particle number by NMR spectroscopy in 2024 individuals from 512 British Caucasian families. Genotypes were 49,094 SNPs in >2,100 cardiometabolic candidate genes/loci as represented on the HumanCVD BeadChip version 2. False discovery rates (FDR) were calculated to account for multiple testing. Analyses on classical HDL-C revealed significant associations (FDR



Author: Kaess, BM - - - Tomaszewski, M - - - Braund, PS - - - Stark, K - - - Rafelt, S - - - Fischer, M - - - Hardwick, R - - - Nelson, C

Source: https://ora.ox.ac.uk/objects/uuid:e10c9876-bb91-4ba0-933e-cf409288ff2d



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