Heterocycle-derived β-S-enals as bifunctional linchpins for the catalytic synthesis of saturated heterocyclesReport as inadecuate




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Reference: Niu, J and Willis, M, (2016). Heterocycle-derived β-S-enals as bifunctional linchpins for the catalytic synthesis of saturated heterocycles. Organic chemistry frontiers : an international journal of organic chemistry / Royal Society of Chemistry.Citable link to this page:

 

Heterocycle-derived β-S-enals as bifunctional linchpins for the catalytic synthesis of saturated heterocycles

Abstract: We demonstrate how heterocycle-derived β-S-enals can be employed as bifunctional substrates in a cascade of two rhodium-catalysed C–C bond forming reactions to deliver substituted heterocyclic products. A single rhodium-catalyst, generated in situ from a commercial salt and ligand combination, is used to promote both an initial alkene or alkyne hydroacylation reaction, and then a Suzuki-type cross-coupling, resulting in a three-component assembly of the targeted heterocycles. Substrates based on N-, O- and S-heterocycles are included, as are a range of alkenes, alkynes and boronic acid derivatives.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Bibliographic Details

Publisher: Royal Society of Chemistry

Publisher Website: http://www.rsc.org/

Journal: Organic chemistry frontiers : an international journal of organic chemistry / Royal Society of Chemistrysee more from them

Publication Website: http://pubs.rsc.org/en/journals/journal/qo

Issue Date: 2016Identifiers

Urn: uuid:e932a94e-024d-4f33-b715-9603fafc5b6b

Source identifier: 611156

Doi: https://doi.org/10.1039/c6qo00057f

Issn: 2052-4129 Item Description

Type: Journal article;

Version: Publisher's version Tiny URL: pubs:611156

Relationships





Author: Niu, J - institutionUniversity of Oxford Oxford, MPLS, Chemistry, Organic Chemistry - - - Willis, M - institutionUniversity of Ox

Source: https://ora.ox.ac.uk/objects/uuid:e932a94e-024d-4f33-b715-9603fafc5b6b



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