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Reference: Tannetta, D, Masliukaite, I, Vatish, M et al., (2016). Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia. Journal of reproductive immunology, 119, 98-106.Citable link to this page:

 

Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia

Abstract: The release of extracellular vesicles (EV) by the syncytiotrophoblast (STB) may be an important mechanism by which the placenta signals to the mother. STB derived EV (STBEV) are comprised predominantly of exosomes (50-150nm) and microvesicles (100-1000nm) that contain bioactive mediators such as proteins, nucleic acids and lipids. They, along with larger syncytial nuclear aggregates are released by the STB into the maternal circulation throughout gestation in normal pregnancy where they appear to have an immunoregulatory role, inhibiting T cell and NK cell responses. In pre-eclampsia (PE) STBEV are released in significantly increased numbers and have pro-inflammatory, anti-angiogenic and procoagulant activity, implicating them in the maternal systemic inflammation, endothelial dysfunction and activation of the clotting system which typifies the disorder. Research has focused on understanding the biological significance of STBEV by measuring their size and repertoire of molecules carried and how they differ in normal pregnancy and PE, using techniques such as Nanoparticle Tracking Analysis, flow cytometry and mass spectrometry. We have also found alterations in STBEV surface glycans associated with PE. The goal is to better understand the role STBEV play in normal pregnancy and PE and whether they are potential biomarkers of placental pathology and therapeutic targets in PE.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's VersionDate of acceptance:2016-08-24 Funder: Medical Research Council   Notes:© 2016 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the Creative Commons BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Bibliographic Details

Publisher: Elsevier

Publisher Website: https://www.elsevier.com/

Journal: Journal of reproductive immunologysee more from them

Publication Website: http://www.journals.elsevier.com/journal-of-reproductive-immunology/

Volume: 119

Issue Date: 2016-08-23

pages:98-106Identifiers

Doi: https://doi.org/10.1016/j.jri.2016.08.008

Issn: 0165-0378

Eissn: 1872-7603

Uuid: uuid:de81047c-bf56-4659-a5d2-8e7b1cbb2775

Urn: uri:de81047c-bf56-4659-a5d2-8e7b1cbb2775

Pubs-id: pubs:642260 Item Description

Type: journal-article;

Language: eng

Version: Publisher's VersionKeywords: exosomes microvesicles placenta preeclampsia syncytiotrophoblast extracellular vesicles

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Author: Tannetta, D - - - Masliukaite, I - - - Vatish, M - Oxford, MSD, Obstetrics and Gynaecology - - - Redman, C - Oxford, MSD, Obstetr

Source: https://ora.ox.ac.uk/objects/uuid:de81047c-bf56-4659-a5d2-8e7b1cbb2775



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